The Human Resources (HR) Competency Model defines the knowledge, skills, abilities, and behaviors essential for HR professionals' effectiveness. In the context of Industry 4.0, this model must incorporate competencies that drive digital transformation, foster innovation, and ensure regulatory compliance particularly in the pharmaceutical industry. This study aims to identify the factors influencing HR competency in the pharmaceutical industry within the Industry 4.0 environment.The research began with a literature review to establish foundational principles. Content analysis was used to extract key indicators, forming the basis of a questionnaire distributed to 15 pharmaceutical industry professionals. These indicators were evaluated through the Delphi method over three rounds. Subsequently, data collection continued via a field survey targeting a purposive sample of 62 pharmaceutical industry managers, experts, and employees. The data were analyzed using confirmatory factor analysis with partial least squares (PLS) in Smart-PLS software. Findings revealed 35 HR competency indicators categorized into five key dimensions: individual competencies (5 indicators), managerial and leadership competencies (14 indicators), innovation and entrepreneurship competencies (5 indicators), strategic competencies (5 indicators), and technological competencies (6 indicators). Based on these results, it is recommended that organizations foster continuous learning by planning and monitoring employees’ daily tasks. This includes assigning challenging projects, encouraging collaboration, and providing on-the-job training opportunities. These strategies can help develop the competencies needed to thrive in the digital era.